Original Papers- UCHIDA Yasuo -
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[2020]
1.Oxidative stress-induced activation of Abl and Src kinases rapidly induces P-glycoprotein internalization via phosphorylation of caveolin-1 on tyrosine-14, decreasing cortisol efflux at the blood-brain barrier.[J Cereb Blood Flow Metab,40(2),(2020),420-436]Uchida Y, Hoshi Y, Tachikawa M, Ohtsuki S, Couraud PO, Suzuki T, Terasaki T
10.1177/0271678X18822801
2.Abundant expression of OCT2, MATE1, OAT1, OAT3, PEPT2, BCRP, MDR1 and xCT transporters in blood-arachnoid barrier of pig, and polarized localizations at CSF- and blood-facing plasma membranes.[Drug Metab Dispos,48(2),(2020),135-145]Uchida Y, Goto R, Takeuchi H, Łuczak M, Usui T, Tachikawa M, Terasaki T
10.1124/dmd.119.089516
3.Distinct roles of ezrin, radixin and moesin in maintaining the plasma membrane localizations and functions of human blood-brain barrier transporters.[J Cereb Blood Flow Metab,Accepted for publication,(2020)]Hoshi Y, Uchida Y, Kuroda T, Tachikawa M, Couraud PO, Suzuki T, Terasaki T
10.1177/0271678X19868880
[2019]
4.Amyloid beta(25-35) impairs docosahexaenoic acid efflux by down-regulating fatty acid transport protein 1 (FATP1/SLC27A1) protein expression in human brain capillary endothelial cells.[J Neurochem,150(4),(2019),385-401]Ochiai Y, Uchida Y, Tachikawa M, Couraud PO, Terasaki T
10.1111/jnc.14722
5.Involvement of claudin-11 in disruption of blood-brain, -spinal cord and -arachnoid barriers in multiple sclerosis.[Mol Neurobiol,56(3),(2019),2039-2056]Y Uchida, T Sumiya, M Tachikawa, T Yamakawa, S Murata, Y Yagi, K Sato, A Stephan, K Ito, S Ohtsuki, PO Couraud, T Suzuki, T Terasaki
10.1007/s12035-018-1207-5
6.Selective Protein Expression Changes of Leukocyte-Migration-Associated Cluster of Differentiation Antigens at the Blood-Brain Barrier in a Lipopolysaccharide-Induced Systemic Inflammation Mouse Model without Alteration of Transporters.[Biol Pharm Bull,42(6),(2019),944-953]Sato K, Tachikawa M, Watanabe M, Uchida Y, Terasaki T
10.1248/bpb.b18-00939
7.Toward a Consensus on Applying Quantitative Liquid Chromatography-Tandem Mass Spectrometry Proteomics in Translational Pharmacology Research: A White Paper.[Clin Pharmacol Ther,106(3),(2019),525-543]Prasad B, Achour B, Artursson P, Hop CECA, Lai Y, Smith PC, Barber J, Wisniewski JR, Spellman D, Uchida Y, Zientek MA, Unadkat JD, Rostami-Hodjegan A
10.1002/cpt.1537
8.Abundant expression of OCT2, MATE1, OAT1, OAT3, PEPT2, BCRP, MDR1 and xCT transporters in blood-arachnoid barrier of pig, and polarized localizations at CSF- and blood-facing plasma membranes.[J Neurochem,Accepted for publication,(2019)]Yasuo Uchida, Ryohei Goto, Hina Takeuchi, Magdalena Łuczak, Takuya Usui, Masanori Tachikawa and Tetsuya Terasaki
9.Quantification of ENT1 and ENT2 proteins at the placental barrier and contribution of these transporters to ribavirin uptake.[J Pharm Sci,(2019),in press-]Nishimura T, Sano Y, Takahashi Y, Noguchi S, Uchida Y, Takagi A, TanakaT, Katakura S, Nakashima E, Tachikawa M, Maruyama T, Terasaki T, Tomi M
[2018]
10.High Expression of UGT1A1/1A6 in Monkey Small Intestine: Comparison of Protein Expression Levels of Cytochromes P450, UDP-Glucuronosyltransferases, and Transporters in Small Intestine of Cynomolgus Monkey and Human.[Mol Pharm.,15(1),(2018),127-140]Akazawa T, Uchida Y, Miyauchi E, Tachikawa M, Ohtsuki S, Terasaki T
10.1021/acs.molpharmaceut.7b00772
11.ATP-binding cassette transporter A subfamily 8 is a sinusoidal efflux transporter for cholesterol and taurocholate in mouse and human liver.[Mol Pharm.,15(2),(2018),343-355]Sasaki K, Tachikawa M, Uchida Y, Hirano S, Kadowaki F, Watanabe M, Ohtsuki S, Terasaki T
10.1021/acs.molpharmaceut.7b00679
12.Drug clearance from cerebrospinal fluid mediated by organic anion transporters 1 (Slc22a6) and 3 (Slc22a8) at arachnoid membrane of rats.[Mol Pharm.,15(3),(2018),911-922]Zhang Z, Tachikawa M, Uchida Y, Terasaki T
10.1021/acs.molpharmaceut.7b00852
13.Identification of blood biomarkers in glioblastoma by SWATH mass spectrometry and quantitative targeted absolute proteomics..[PloS one,13(3),(2018),e0193799-]Miyauchi E, Furuta T, Ohtsuki S, Tachikawa M, Uchida Y, Sabit H, Obuchi W, Baba T, Watanabe M, Terasaki T, Nakada M
10.1371/journal.pone.0193799
http://www.ncbi.nlm.nih.gov/pubmed/29513714
[2017]
14.Application of Quantitative Targeted Absolute Proteomics to Profile Protein Expression Changes of Hepatic Transporters and Metabolizing Enzymes During Cholic Acid-Promoted Liver Regeneration.[JOURNAL OF PHARMACEUTICAL SCIENCES,106(9),(2017),2499-2508]Takayuki Miura, Masanori Tachikawa, Hideo Ohtsuka, Koji Fukase, Shun Nakayama, Naoaki Sakata, Fuyuhiko Motoi, Takeshi Naitoh, Yu Katayose, Yasuo Uchida, Sumio Ohtsuki, Tetsuya Terasaki, Michiaki Unno
10.1016/j.xphs.2017.02.018
http://www.ncbi.nlm.nih.gov/pubmed/28249806 http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=TohokuUniv&SrcApp=TohokuUniv&DestLinkType=FullRecord&KeyUT=WOS:000417339900040&DestApp=WOS
15.The blood-brain barrier fatty acid transport protein 1 (FATP1/SLC27A1) supplies docosahexaenoic acid to the brain, and insulin facilitates transport.[JOURNAL OF NEUROCHEMISTRY,141(3),(2017),400-412]Yusuke Ochiai, Yasuo Uchida, Sumio Ohtsuki, Masanori Tachikawa, Sanshiro Aizawa, Tetsuya Terasaki
10.1111/jnc.13943
http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=TohokuUniv&SrcApp=TohokuUniv&DestLinkType=FullRecord&KeyUT=WOS:000399654500008&DestApp=WOS
16.All-trans retinoic acid enhances gemcitabine cytotoxicity in human pancreatic cancer cell line AsPC-1 by up-regulating protein expression of deoxycytidine kinase.[EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES,103,(2017),116-121]Hiroki Kuroda, Masanori Tachikawa, Yasuo Uchida, Koetsu Inoue, Hideo Ohtsuka, Sumio Ohtsuki, Michiaki Unno, Tetsuya Terasaki
10.1016/j.ejps.2017.02.021
http://www.ncbi.nlm.nih.gov/pubmed/28215943 http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=TohokuUniv&SrcApp=TohokuUniv&DestLinkType=FullRecord&KeyUT=WOS:000402349700014&DestApp=WOS
17.Actin filament-associated protein 1 (AFAP-1) is a key mediator in inflammatory signaling-induced rapid attenuation of intrinsic P-gp function in human brain capillary endothelial cells.[JOURNAL OF NEUROCHEMISTRY,141(2),(2017),247-262]Yutaro Hoshi, Yasuo Uchida, Masanori Tachikawa, Sumio Ohtsuki, Tetsuya Terasaki
10.1111/jnc.13960
http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=TohokuUniv&SrcApp=TohokuUniv&DestLinkType=FullRecord&KeyUT=WOS:000399003300008&DestApp=WOS
18.Inner blood-retinal barrier dominantly expresses breast cancer resistance protein: Comparative quantitative targeted absolute proteomics (QTAP) study of CNS barriers in pig.[Mol Pharm.,14(11),(2017),3729-3738]Zhang Z, Uchida Y, Hirano S, Ando D, Kubo Y, Auriola S, Akanuma S, Hosoya K, Urtti A, Terasaki T, Tachikawa M
10.1021/acs.molpharmaceut.7b00493
[2016]
19.Quantitative targeted absolute proteomics for 28 transporters in brush-border and basolateral membrane fractions of rat kidney.[J Pharm Sci.,105,(2016),1011-1016]Uchida Y, Toyohara T, Ohtsuki S, Moriyama Y, Abe T and Terasaki T
10.1002/jps.24645
20.Quantitative Targeted Absolute Proteomics of Transporters and Pharmacoproteomics-Based Reconstruction of P-Glycoprotein Function in Mouse Small Intestine.[Mol Pharm.,13(7),(2016),2443-2456]Akazawa T, Uchida Y, Tachikawa M, Ohtsuki S, Terasaki T
10.1021/acs.molpharmaceut.6b00196
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