Researchers Information

Research Activities

Books, Original Papers & Review Papers
OGAWA Tomohisa
Graduate School of Life Sciences
Department of Molecular and Chemical Life Sciences
Division of Chemical Biology
Laboratory of Applied Biological Molecular Science
Associate Professor
Research Fields
  • Applied Biochemistry(Protein engineering)
  • Molecular biology(Molecular evolution)
  • Structural biochemistry(Biochemistry)
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Research Subjects
  • Molecular diversification of protein structures and functions via accelerated evolution(1989-)
  • Molecular Mechanism of Bio-mineralization and Its Development to The Novel Nano-Technology(2004-)
  • Study on the stucture and function relationship of lectins(1996-)
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protein, protein engineering, molecular evolution, genome, lectin, biominerarization, snake venom
Academic Society Membership
  • 日本生化学会
  • 日本農芸化学会
  • 日本化学会
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Activity of Academic Society (Post)
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    Protein Engineering -Technology and Application: Experimental molecular archeology: reconstruction of ancestral mutants and evolutionary history of proteins as a new approach in protein engineering..[InTech,(2013)]Tomohisa Ogawa and Tsuyoshi Shirai

    Lectin Methods and Protocols Part4, Method in Molecular Biology: Tracing Ancestral Specificity of Lectins: Ancestral Sequence Reconstruction Method as a New Approach in Protein Engineering.[Humana Press,(2014)]Tomohisa Ogawa and Tsuyoshi Shirai

    生物化学実験法 52 レクチン研究法.[Japan Scientific Societies Press,(2007)]小川智久,村本光二

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    Original Papers

    Novel Matrix Proteins of Pteria penguin Pearl Oyster Shell Nacre Homologous to the Jacalin-Related β-Prism Fold Lectins.[PLoS ONE,9(11),(2014),e112326-]Naganuma T, Hoshino W, Shikanai Y, Sato R, Liu K, Sato S, Muramoto K, Osada M, Yoshimi K, Ogawa T.

    Tracing Protein Evolution through Ancestral Structures of Fish Galectin..[Structure,19(5),(2011),711-721]Ayumu Konno, Atsushi Kitagawa, Mizuki Watanabe, Tomohisa Ogawa, Tsuyoshi Shirai

    Allosteric regulation of the carbohydrate-binding ability of a novel conger Eel galectin by D-mannoside.[Journal of Biological Chemistry,287,(2012),31061-31072]Mizuki Watanabe, Osamu Nakamura, Koji Muramoto and Tomohisa Ogawa

    Reconstruction of a Probable Ancestral Form of Conger Eel Galectins Revealed.[Molecular Biology and Evolution,24(11),(2007),2504-2514]Ayumu Konno, Tomohisa Ogawa, Tsuyoshi Shirai, Koji Muramoto

    Accelerated evolution of Trimeresurus flavoviridis venom gland phospholipase A2 isozymes.[Proceedings of the National Academy of Science of the United State of America,90(13),(1993),5964-5968]NAKASHIMA K, OGAWA T, ODA N, HATTORI M, SAKAKI Y, KIHARA H, OHNO M

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    Review Papers

    Molecular Evolution of Snake Toxins : Is the Functional Diversity of Snake Toxins Associated with a Mechanism of Accelerated Evolution?.[ACADEMIC PRESS INC, 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA PROGRESS IN NUCLEIC ACID RESEARCH AND MOLECULAR BIOLOGY,59, (1998), 307-364]Ohno M, Menez R, Ogawa T, Danse JM, Shimohigashi Y, Fromen C, Ducancel F, Zinn-Justin S, Le Du MH, Boulain JC, Tamiya T, Menez A

    Changes of protein structure and function on accelerated evolution: A case of fish galectin.[Kyoritu publications Co. Protein, Nucleic acid and Enzyme,48(14), (2003), 1913-1919]Tsuyoshi Shirai, Clara Shionyu-Mitsuyama, Tomohisa Ogawa

    Molecular diversity and accelerated evolution of C-type lectin-like proteins from snake venom.[Toxicon,45(1), (2005), 1-14]Ogawa T, Chijiwa T, Oda-Ueda N, Ohno M

    Molecular diversity of proteins in biological offense and defense systems..[Molecular Diversity,10(4), (2006), 511-514]Ogawa Tomohisa

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    Honours, Awards and Prizes
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