Researchers Information

Books, Original Papers & Review Papers
Graduate School of Agriculture
Division of Bioscience and Biotechnology for Future Bioindustries
Department of Science of Food Function and Health
Laboratory of Animal Products Chemistry
Director of CFAI
Date of Birth
Research Fields
  • Livestock science/meadow studies
  • Food science
  • Applied molecular cell biology(Applied Molecular Cell Biology)
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Research Subjects
  • Fundamental study of food immunology(2000-)
  • Development of immune functional ecofeed in domestic animal(2010-)
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Lactic acid bacteria,Probiotics, Immunobiotics, Immunogenics, Mucosal immunoregulation,Bio-Defense, Molecular food immunology
Academic Society Membership
  • 日本畜産学会
  • 日本農芸化学会
  • Japanese Association of Food Immunology
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Activity of Academic Society (Post)
  • Japanese Association for Food Immunology, 幹事(2006-)
  • Japanese Society for Lactic Acid Bacteria, 理事(庶務)(2011-2015)
  • 東北畜産学会, 幹事長(2005-2007)
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Probiotics: Immunobiotics and Immunogenics (Eds. H. Kitazawa, J. Villena & S. Alvarez).[CRC Press,(2013)]H. Kitazawa, J. Villena, S. Alvarez

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Original Papers

Transcriptomic analysis of the innate antiviral immune response in porcine intestinal epithelial cells: influence of immunobiotic lactobacilli.[Front. Immunol.,8(57),(2017),1-15]Albarracin, L.†, H. Kobayashi†, H. Iida, N. Sato, T. Nochi, H. Aso, S. Salva, S. Alvarez, H. Kitazawa*, J. Villena* (†: Equal contribution)

Immunobiotic Lactobacillus jensenii as immune-health promoting factor to improve growth performance and productivity in post-weaning pigs.[BMC Immunol.,15(24),(2014),1-18]Suda, Y., J. Villena, Y. Takahashi, S. Hosoya, Y. Tomosada, K. Tsukida, T. Shimazu, H. Aso, M. Tohno, M. Ishida, S. Makino, S. Ikegami, H. Kitazawa*

Immunobiotic Lactobacillus jensenii elicit anti-inflammatory activity in porcine intestinal epithelial cells by modulating negative regulators of the toll-like receptor signaling pathway..[Infection and Immunity,80(1),(2012),276-288]Shimazu, T.#, J. Villena#, M. Tohno, H. Fujie , S. Hosoya, T. Shimosato, H. Aso, Y. Suda, Y. Kawai, T. Saito, S. Makino, S. Ikegami, H. Itoh, H. Kitazawa*. (#; Equal contribution).

Immunobiotic lactic acid bacteria beneficially regulate immune response triggered by poly(I:C) in porcine intestinal epithelial cells..[Veterinary Research,42(111),(2011),1-13]Hosoya, S.#, J. Villena#, T. Shimazu, M. Tohno, H. Fujie, E. Chiba, T. Shimosato, H. Aso, Y. Suda, Y. Kawai, T, Saito, S. Alvarez, S. Ikegami, H. Itoh, H. Kitazawa*. (#; Equal contribution).

Strong immunostimulatory activity of AToligodeoxynucleotide requires a six-base loop with a self-stabilized 5'-C...G-3' stem structure.[Cellular Microbiology,8(3),(2006),485-495]Shimosato, T., T. Kimura, M. Tohno, I.D. Iliev, S. Katoh, Y. Ito, Y. Kawai, T. Sasaki, T. Saito and H. Kitazawa*

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Review Papers

Regulation of Toll-like receptors-mediated inflammation by immunobiotics in bovine intestinal epitheliocytes: role of signalling pathways and negative regulators.[Front. Immunol.,5(421), (2014), 1-10]Villena, J., H. Aso, H. Kitazawa*

Modulation of respiratory TLR3-antiviral response by probiotic microorganisms: lessons learned from Lactobacillus rhamnosus CRL1505.[Front. Immunol.,5(201), (2014), 1-15]Kitazawa, H., J. Villena*

Modulation of intestinal TLR4-inflammatory signaling pathways by probiotic microorganisms: lessons learned from Lactobacillus jensenii TL2937.[Front. Immunol.,4(512), (2014), 1-12]Villena, J., H. Kitazawa*

安全な持続的家畜生産のためのイムノバイオティック革命.[日本家畜臨床感染症研究会誌,5(3), (2010), 79-83]北澤春樹*、須田義人、麻生 久

Development of molecular immunoassay system for probiotics via Toll-like receptors based on food immunology.[Anim. Sci. J.,79, (2008), 11-21]Kitazawa, H.*, M. Tohno, T. Shimosato, T. Saito

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Honours, Awards and Prizes
  • 森永奉仕会賞(2013)
  • 日本食品免疫学会賞(2012)
  • Animal Science Journal Excellent Paper Award(2011)
  • 「世界の発酵乳」論文賞(2008)
  • 日本畜産学会賞(2006)
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Activity of External Organization
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    Mail Address
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