Researchers Information

Books, Original Papers & Review Papers
Graduate School of Agriculture
Division of Bioscience and Biotechnology for Future Bioindustries
Associate Professor
Vice director (Education), Head of Livestock Immunology Unit, CFAI
Date of Birth
Research Fields
  • Livestock science/meadow studies
  • Food science
  • Applied molecular cell biology(Applied Molecular Cell Biology)
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Research Subjects
  • Fundamental study of food immunology(2000-)
  • Development of immune functional ecofeed in domestic animal(2010-)
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Fermented milk,Lactic acid bacteria,Mucosal immunoregulation,Bio-Defense, Molecular food immunology
Academic Society Membership
  • 日本畜産学会
  • 日本農芸化学会
  • Japanese Association of Food Immunology
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Activity of Academic Society (Post)
  • Japanese Association for Food Immunology, 幹事(2006-)
  • Japanese Society for Lactic Acid Bacteria, 理事(庶務)(2011-2015)
  • 東北畜産学会, 幹事長(2005-2007)
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Probiotics: Immunobiotics and Immunogenics (Eds. H. Kitazawa, J. Villena & S. Alvarez).[CRC Press,(2013)]H. Kitazawa, J. Villena, S. Alvarez

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Original Papers

Transcriptomic analysis of the innate antiviral immune response in porcine intestinal epithelial cells: influence of immunobiotic lactobacilli.[Front. Immunol.,8(57),(2017),1-15]Albarracin, L.†, H. Kobayashi†, H. Iida, N. Sato, T. Nochi, H. Aso, S. Salva, S. Alvarez, H. Kitazawa*, J. Villena* (†: Equal contribution)

Immunobiotic Lactobacillus jensenii as immune-health promoting factor to improve growth performance and productivity in post-weaning pigs.[BMC Immunol.,15(24),(2014),1-18]Suda, Y., J. Villena, Y. Takahashi, S. Hosoya, Y. Tomosada, K. Tsukida, T. Shimazu, H. Aso, M. Tohno, M. Ishida, S. Makino, S. Ikegami, H. Kitazawa*

Immunobiotic Lactobacillus jensenii elicit anti-inflammatory activity in porcine intestinal epithelial cells by modulating negative regulators of the toll-like receptor signaling pathway..[Infection and Immunity,80(1),(2012),276-288]Shimazu, T.#, J. Villena#, M. Tohno, H. Fujie , S. Hosoya, T. Shimosato, H. Aso, Y. Suda, Y. Kawai, T. Saito, S. Makino, S. Ikegami, H. Itoh, H. Kitazawa*. (#; Equal contribution).

Immunobiotic lactic acid bacteria beneficially regulate immune response triggered by poly(I:C) in porcine intestinal epithelial cells..[Veterinary Research,42(111),(2011),1-13]Hosoya, S.#, J. Villena#, T. Shimazu, M. Tohno, H. Fujie, E. Chiba, T. Shimosato, H. Aso, Y. Suda, Y. Kawai, T, Saito, S. Alvarez, S. Ikegami, H. Itoh, H. Kitazawa*. (#; Equal contribution).

Strong immunostimulatory activity of AToligodeoxynucleotide requires a six-base loop with a self-stabilized 5'-C...G-3' stem structure.[Cellular Microbiology,8(3),(2006),485-495]Shimosato, T., T. Kimura, M. Tohno, I.D. Iliev, S. Katoh, Y. Ito, Y. Kawai, T. Sasaki, T. Saito and H. Kitazawa*

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Review Papers

Regulation of Toll-like receptors-mediated inflammation by immunobiotics in bovine intestinal epitheliocytes: role of signalling pathways and negative regulators.[Front. Immunol.,5(421), (2014), 1-10]Villena, J., H. Aso, H. Kitazawa*

Modulation of respiratory TLR3-antiviral response by probiotic microorganisms: lessons learned from Lactobacillus rhamnosus CRL1505.[Front. Immunol.,5(201), (2014), 1-15]Kitazawa, H., J. Villena*

Modulation of intestinal TLR4-inflammatory signaling pathways by probiotic microorganisms: lessons learned from Lactobacillus jensenii TL2937.[Front. Immunol.,4(512), (2014), 1-12]Villena, J., H. Kitazawa*

安全な持続的家畜生産のためのイムノバイオティック革命.[日本家畜臨床感染症研究会誌,5(3), (2010), 79-83]北澤春樹*、須田義人、麻生 久

Development of molecular immunoassay system for probiotics via Toll-like receptors based on food immunology.[Anim. Sci. J.,79, (2008), 11-21]Kitazawa, H.*, M. Tohno, T. Shimosato, T. Saito

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Honours, Awards and Prizes
  • 森永奉仕会賞(2013)
  • 日本食品免疫学会賞(2012)
  • Animal Science Journal Excellent Paper Award(2011)
  • 「世界の発酵乳」論文賞(2008)
  • 日本畜産学会賞(2006)
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Activity of External Organization
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    Mail Address
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