Researchers Information

Research Activities

Books, Original Papers & Review Papers
UCHIDA Takafumi
Graduate School of Agriculture
Division of Life Science
Department of Molecular and Cell Biology
Laboratory of Enzymology
Tohoku University Brain Science Center
Date of Birth
Academic Degree
Research Fields
  • Applied molecular cell biology
  • Molecular biology
  • Functional biochemistry
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Research Subjects
  • Application of Prolyl Isomerase Pin1 Family Molecules to Health(2000-)
  • Application of Regulatory Enzymes for Differentiation of Stem Cell to Health(2004-)
  • Enzymes related to cancer(2000-)
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prolyl isomerase, phosphorylated proteins, microtubule, structure and function, enzyme, drug discovery
Academic Society Membership
  • 日本農芸化学会
  • 日本生化学会
  • 日本分子生物学会
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Activity of Academic Society (Post)
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    “Luminescence Biotechnology: Instruments and Applications”.[CRC Press LLC (New York),(2002)]Hosaka, S, and Uchida,T. (Ed.Van Dyke & Van Dyke)

    Polymers in Medicine.[Plenum Publishing Co. (New York),(1986)]Uchida, T., Suzuki, K., Hosaka, S. and Fujikura, T. (Eds. Chiellini, E., Giusti, P., Migliaresi, C. and Nicolais, L.)

    Macrophage Biology.[Alan R. Liss, Inc. (New York),(1985)]Uchida, T. and Hosaka, S. (eds. Richards, S. and Kojima, M.)

    免疫実験操作法, XIII.[(1984)]鈴木和男、内田隆史

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    Original Papers

    Mice lacking Pin1 develop normally, but are defective in entering cell cycle from G0 arrest..[Biochem Biophys Res Commun,,265,(1999),658-663]corresponding author

    The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults..[Nature,419,(2002),853-857]Zacchi, P., Gostissa, M., Uchida, T., Salvagno, C., Avolio F., Volinia, S., Ronai, Z., Blandino, G., Schneider, C. and Del Sal G.

    The prolyl isomerase Pin1 is a novel regulator of phosphorylated p53 in genotoxic response..[Nature,419,(2002),849-853]Zheng, H., You, H., Zhou, X-Z., Murray, S.A., Uchida,T., Wulf, G., Gu, L., Tang, X., Lu, KP and Xiao, J. Z-X

    A signaling pathway controlling myc degradation that impacts oncogenic transformation of human cells..[Nature Cell Biology,6(4),(2004),308-318]Yeh, E, Cunnigham, M., Arnold, H., Chasse, D., Monteith, T., Ivaldi, G., Hahn, WC., Stukenberg, T., Shenolikar, S., Uchida, T., Counter, CM., Nevins, JR., Means, AR. and Sears, R.

    Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration..[Nature,424,(2003),556-561]Liou,YC, Sun,A., Ryo,A., Zhou,X.Z., Yu, ZX., Huang,HK., Uchida, T., Bronson,R., Bing,G., Li,X., Hunter,T. and Lu,KP.

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    Review Papers

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    Honours, Awards and Prizes
    • 農芸化学会研究企画賞(2007)
    • James Hudson Brown - Alexander B. Cox Fellowship (Yale Univ. SCM)(1987)
    • アメリカ癌学会トレーニング賞(2000)
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    Activity of External Organization
    • Nature Review Molecular Cell BIology(2006)
    • Nature Chemical Biology(2010)
    • Nature Structural and Molecular Biology(2012)
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    Mail Address
    Mail Address
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