Researchers Information
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Books, Original Papers & Review Papers
Name
UCHIDA Yasuo
Affiliation
Graduate School of Pharmaceutical Sciences & Faculty of Pharmaceutical Sciences
Division of Bio-Pharmaceutical Science
Molecular Pharmaceutics
Laboratory of Membrane Transport and Drug Targeting
Assigned Class
Graduate School of Pharmaceutical Sciences & Faculty of Pharmaceutical Sciences
Division of Bio-Pharmaceutical Science
Molecular Pharmaceutics
Laboratory of Membrane Transport and Drug Targeting

Title
Assistant Professor
Date of Birth
1983.12
Academic Degree
Ph.D.
Research Fields
  • Clinical pharmaceutical science(Proteomics-based pharmacokinetics (Pharmacoproteomics))
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Research Subjects
  • Investigation of brain barrier transportsome by phosphoproteomics and Understanding of disease brain barrier(2011-)
  • Proteomics-based reconstruction of brain barrier transport function and prediction of brain drug distribution(2007-)
  • Antibody-free analysis for the intra-cellular and intra-organ localizations of transporters, receptors and the other functional molecules(2010-)
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Keywords
Pharmacoproteomics, ADME, Blood-brain barrier, Transporters, Proteomics, Pharmacokinetics
Academic Society Membership
  • International Brain Barriers Society
  • American Association of Pharmaceutical Scientists
  • International Society for the Study of Xenobiotics
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Books

Blood-brain barrier (BBB) pharmacoproteomics: a new research field opened up by quantitative targeted absolute proteomics (QTAP). IN Drug Delivery to the Brain – Physiological Concepts, Methodologies and Approaches, Margareta Hammarlund-Udenaes, Elizabeth de Lange and Robert Thorne (Ed.).[Springer, pp 63-100,(2014)]Y Uchida, M Tachikawa, S Ohtsuki and T Terasaki


Chapter 10 Pharmacoproteomics. IN Essential Manual for Pharmaceutical Experiment, Y Watanabe, Y Deguchi and K Ito (Ed.).[Nankodo Co., Ltd. Tokyo, pp312-324,(2014)]Uchida Y, Tachikawa M


The role of drug transporters at blood-brain barrier. IN The World of Transportsome -From Headstream of Membrane Transport Research to the Future-, Y Kanai, H Takeshima, Y Mori and Y Kubo (Ed.).[Kyoto Hirokawa Publishing Inc. Tokyo, pp282-290,(2011)]Y Uchida, S Ohtsuki, K Ohmine and T Terasaki


Recent progress in blood-brain barrier and blood-CSF barrier transport research: Pharmaceutical relevance for drug delivery to the brain. IN Drug Delivery to the Brain – Physiological Concepts, Methodologies and Approaches, Margareta Hammarlund-Udenaes, Elizabeth de Lange and Robert Thorne (Ed.).[Springer, pp 23-62,(2014)]M Tachikawa, Y Uchida, S Ohtsuki and T Terasaki


Blood-brain barrier (DOI:10.14931/bsd.3373). IN Brain Science Dictionary..[(2015)]Masanori Tachikawa, Yasuo Uchida, Tetsuya Terasaki. http://bsd.neuroinf.jp/wiki/%E8%A1%80%E6%B6%B2%E8%84%B3%E9%96%A2%E9%96%80


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Original Papers

Quantitative targeted absolute proteomics of human blood-brain barrier transporters and receptors..[J Neurochem,117(2),(2011),333-345]Y Uchida, S Ohtsuki, Y Katsukura, C Ikeda, T Suzuki, J Kamiie and T Terasaki
10.1111/j.1471-4159.2011.07208.x
http://www.ncbi.nlm.nih.gov/pubmed/21291474


Blood-brain barrier (BBB) pharmacoproteomics: reconstruction of in vivo brain distribution of 11 P-glycoprotein substrates based on the BBB transporter protein concentration, in vitro intrinsic transport activity, and unbound fraction in plasma and brain in mice..[J Pharmacol Exp Ther,339(2),(2011),579-588]Y. Uchida, S. Ohtsuki, J. Kamiie, T. Terasaki
10.1124/jpet.111.184200
http://www.ncbi.nlm.nih.gov/pubmed/21828264


Blood-brain barrier pharmacoproteomics-based reconstruction of the in vivo brain distribution of P-glycoprotein substrates in cynomolgus monkeys..[J Pharmacol Exp Ther,350(3),(2014),578-588]Uchida Y, Wakayama K, Ohtsuki S, Chiba M, Ohe T, Ishii Y, Terasaki T
10.1124/jpet.114.214536
http://www.ncbi.nlm.nih.gov/pubmed/24947467


A study protocol for quantitative targeted absolute proteomics (QTAP) by LC-MS/MS: application for inter-strain differences in protein expression levels of transporters, receptors, claudin-5, and marker proteins at the blood-brain barrier in ddY, FVB, and C57BL/6J mice..[Fluids Barriers CNS,10(1),(2013),21]Y Uchida, M Tachikawa, W Obuchi, Y Hoshi, Y Tomioka, S Ohtsuki, T Terasaki
10.1186/2045-8118-10-21
http://www.ncbi.nlm.nih.gov/pubmed/23758935


Quantitative targeted absolute proteomics of rat blood-cerebrospinal fluid barrier transporters: comparison with a human specimen..[J Neurochem,(2015)]Uchida Y, Zhang Z, Tachikawa M and Terasaki T
10.1111/jnc.13147
http://www.ncbi.nlm.nih.gov/pubmed/25951748


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Review Papers

Quantitative targeted absolute proteomics in blood-brain barrier.[Vascular Biology & Medicine,14(4), (2013), 399-409]Y Uchida, K Sato, H Kuroda, Y Hoshi, M Tachikawa, T Terasaki


Reconstruction of blood-brain barrier transport function from in vitro system based on quantitative targeted absolute proteomics (QTAP).[Cell Technology,32, (2013), 955-961]Y Uchida, M Tachikawa, T Terasaki


Pharmacoproteomics (PPx)-based blood-brain barrier research.[IdenshiIgaku MOOK,19, (2011), 148-154]Y Uchida, S Ohtsuki and T Terasaki


New insight of transporter research based on quantitative targeted absolute proteomics.[Cell Technology,31, (2012), 587-588]Y Uchida, M Tachikawa, T Terasaki


Quantitative absolute expression profile of blood-brain barrier transportsome : similarity and difference between animal species, strains and wild/knockout mice.[Brain 21,16(3), (2013), 46-52]Y Uchida, M Tachikawa, Y Hoshi, T Terasaki


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Honours, Awards and Prizes
  • AAPS Pharmaceutical Research Meritorious Manuscript Award(2010)
  • The 30th (2013) Inoue Research Award for Young Scientists(2014)
  • 8th Cerebral Vascular Biology International Conference, Outstanding Presentation Award(2009)
  • APSTJ 28th Annual Conference, Best Presentation Award(2013)
  • Tohoku university president prize(2006)
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Web Site
http://www.pharm.tohoku.ac.jp/~soutatsu/dds/profile/uchida.htm
Mail Address
Mail Address
Updated on
2019.09.16
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